Doxylamine

Doxylamine is a first-generation antihistamine. It blocks certain histamine receptors and thus has a calming effect on the central nervous system. As a side effect or if taken in too high a dose, it can cause drowsiness.

How does it help with nausea during pregnancy?

Through its effect on the nervous system, doxylamine also influences signaling pathways involved in the development of nausea. This can help to reduce feelings of nausea. During pregnancy, it is used in targeted, low doses and is often taken in the evening, as it can cause drowsiness.

During pregnancy, doxylamine succinate is often used in combination with vitamin B6 (pyridoxine) because their mechanisms of action complement each other. Possible side effects include fatigue, dry mouth, or drowsiness, usually depending on the dosage. Use should be supervised by a doctor, especially in cases of pre-existing conditions or simultaneous use of other sedative medications.